Fig. 2

KRT6A knockdown relieves the development of rosacea. A Schematic diagram of AAV-shKRT6A-injected mice treated with LL37 or PBS. B The back skins of the control group and AAV shRNA-mediated knockdown of the Krt6a group treated with or without LL37 (n = 6/group). C The severity of the rosacea-like phenotype was evaluated on account of the redness area and score. D HE staining of lesional skin sections from (B). E Quantitative result of HE staining for dermal cellular infiltrates is shown. Data represent the mean ± SEM. F Immunostaining of CD4 in skin sections. G Quantitative result of CD4⁺ T cells is shown. Data represent the mean ± SEM. H Immunostaining of CD31 in skin sections. G Quantitative result of CD31⁺ vessels is shown. Data represent the mean ± SEM. 1-way ANOVA with Bonferroni’s post hoc test (C, E, G, I) was used