Fig. 1

KRT6A is up-regulated in rosacea. A GO analysis showed that differentially expressed genes in rosacea lesions were associated with immune response and skin development. B The mRNA expression levels of KRT6A in the skin of HS (n = 19) and patients with rosacea (n = 46). C Correlation analysis between KRT6A expression and IGA score in rosacea lesions. D Representative immunohistochemistry (IHC) images showing the expression of KRT6A in rosacea lesions and healthy controls. E Representative immunofluorescence (IF) images showing the expression of KRT6A in LL37-induced rosacea-like mice. F RT-qPCR analysis showing the mRNA expression of KRT6A in the skin of LL37-induced rosacea-like mice and controls. G Representative western blot images showing the expression of KRT6A in LL37-treated keratinocytes. Quantification of relative protein expression is shown in the bottom panel. Scr: scrambled 37 amino acid polypeptide sequences. *P < 0.05; **P < 0.01, compare with the 0 group; #P < 0.05; ##P < 0.01, compare with the Scr group. All experiments were performed in 3 independent biological replicates. Data represents the mean ± SEM. Two-tailed unpaired Student’s t-test (B, F, G) was used